Vasoactive Intestinal Peptide (VIP)

Overview

Vasoactive Intestinal Peptide (VIP) is a naturally occurring neuropeptide found in the gastrointestinal tract, pancreas, and central nervous system. It is widely investigated for its role in immune regulation, inflammation, neuroprotection, gastrointestinal biology, pulmonary function, and cardiovascular research. VIP primarily exerts its biological activity through VPAC1, VPAC2, and PAC1 receptors, making it an important research tool for studying cellular signaling and neuroimmune communication.

Product Specifications

• Product Name: Vasoactive Intestinal Peptide (VIP)
• Other Known Titles: PHM27, Vasoactive Intestinal Polypeptide
• Molecular Formula: C147H237N43O43S
• Molecular Weight: 3326.8 g/mol
• Sequence: HSDAVFTDNYXRLRKQMAVKKYLNSXLN
• Form: Lyophilized Powder
• Application: Research Use Only

Research Overview

VIP has been extensively studied for its involvement in immune modulation, inflammatory signaling, neuroprotection, pulmonary biology, gastrointestinal function, and cardiovascular regulation. Researchers continue investigating its effects on cytokine signaling, intestinal barrier integrity, neuronal survival, and receptor-mediated cellular communication.

Current scientific understanding is based primarily on cell-culture studies, biochemical assays, and preclinical animal research.

Mechanism of Action (Research Only)

Experimental studies suggest that VIP binds to VPAC1, VPAC2, and PAC1 G-protein coupled receptors, activating intracellular signaling pathways associated with immune regulation, inflammation, neuronal function, and cellular communication. Researchers have also investigated its influence on cAMP signaling, cytokine production, blood-brain barrier function, and tissue homeostasis under controlled laboratory conditions.

Potential Research Applications

Current laboratory investigations include:

• Immune system regulation
• Inflammation research
• Neuroprotection studies
• Gastrointestinal biology
• Inflammatory bowel disease models
• Pulmonary function research
• Pulmonary fibrosis studies
• Cardiac fibrosis research
• Blood-brain barrier research
• Neurodegenerative disease studies
• Organ transplant immunology
• Cytokine signaling
• GPCR signaling pathways
• Comparative peptide research

Storage

• Store lyophilized peptide in a cool, dry environment.
• After reconstitution, refrigerate at 2°C–8°C.
• Protect from heat, moisture, and direct light.
• Avoid repeated freeze-thaw cycles to preserve peptide stability.

Future Research

VIP continues to be investigated for its potential role in immune regulation, neurobiology, pulmonary disease, gastrointestinal health, cardiovascular biology, and inflammatory signaling. Ongoing preclinical studies aim to further understand its biological mechanisms and broader applications in laboratory science.