FOXO4-DRI Peptide

Overview

FOXO4-DRI is a synthetic D-retro-inverso peptide derived from the FOXO4 protein and is widely investigated in cellular senescence and healthy aging research. By incorporating D-amino acids, FOXO4-DRI offers improved stability and resistance to enzymatic degradation compared to the native peptide. Research suggests it may selectively disrupt the interaction between FOXO4 and p53, potentially promoting the removal of senescent (aged) cells through apoptosis while preserving normal cellular functions.

Product Specifications

• Other Known Titles: Forkhead Box Protein O4, Proxofim, FOXO4a, AFX, AFX1, MLLT7
• Molecular Formula: C228H388N86O64
• Molecular Weight: 5358.05 g/mol
• Sequence: H-D-Leu-D-Thr-D-Leu-D-Arg-D-Lys-D-Glu-D-Pro-D-Ala-D-Ser-D-Glu-D-Ile-D-Ala-D-Gln-D-Ser-D-Ile-D-Leu-D-Glu-D-Ala-D-Tyr-D-Ser-D-Gln-D-Asn-D-Gly-D-Trp-D-Ala-D-Asn-D-Arg-D-Arg-D-Ser-D-Gly-D-Gly-D-Lys-D-Arg-D-Pro-D-Pro-D-Pro-D-Arg-D-Arg-D-Arg-D-Gln-D-Arg-D-Arg-D-Lys-D-Lys-D-Arg-D-Gly-OH

Research Overview

FOXO4-DRI has been extensively studied for its potential role in cellular senescence, apoptosis, tissue regeneration, healthy aging, and protein signaling. Experimental research suggests the peptide may interfere with FOXO4-p53 binding, allowing p53 to activate apoptotic pathways that selectively remove senescent cells.

Scientists continue investigating its role in tissue renewal, cellular differentiation, oxidative stress regulation, insulin signaling, and age-related biological processes using cell culture and animal models.

Mechanism of Action (Research Only)

Research indicates that FOXO4-DRI may disrupt the interaction between the FOXO4 transcription factor and the p53 protein. This interaction has been investigated as a mechanism for restoring p53-mediated apoptosis in senescent cells, potentially reducing the accumulation of aged cells while maintaining normal antioxidant defenses.

Current understanding is based on preclinical laboratory studies and experimental models.

Potential Research Applications

Current laboratory investigations include:

• Cellular senescence research
• Healthy aging and longevity studies
• Apoptosis signaling
• Tissue regeneration
• Cell differentiation
• Protein-protein interaction research
• Insulin signaling studies
• Oxidative stress biology
• Cardiovascular research
• Neurodegenerative disease research
• Proteasome and autophagy research
• Experimental peptide therapeutics

Future Research

FOXO4-DRI continues to be investigated as a promising research peptide for understanding cellular aging, senescent cell clearance, tissue regeneration, metabolic signaling, and age-related biological processes. Additional preclinical research is required to further clarify its mechanisms, long-term safety, and broader scientific applications.