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TB-500

Price range: $59.00 through $159.00

Research Use Only

All products are intended solely for laboratory research and are not for human or animal consumption. By purchasing, the buyer agrees to use these products in compliance with all applicable laws.

TB-500 Overview

TB-500 is a synthetic peptide fragment derived from thymosin beta-4, a naturally occurring protein studied for its role in molecular signaling and pathway dynamics. Research has focused on its potential influence on matrix remodeling, angiogenesis, and molecular migration in preclinical and laboratory models. TB-500 is of particular interest in investigations involving connective tissue, structural dynamics, and extracellular matrix pathways.

Goldstein A.L. et al. (2005). 

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SKU: SKU-TB-500-------------- Category:

History

Thymosin Beta-4, the parent protein of TB-500, was first isolated in the 1960s by Allan L. Goldstein and colleagues during research into thymus-derived peptides. TB-500 was later synthesized as a research fragment to enable focused study on Tβ4’s signaling functions. Since its development, it has been investigated across models of angiogenesis, structural dynamics, and molecular migration, with growing interest in its systemic regulatory potential.

Goldstein A.L., Hannappel E. et al. (2012).

TB-500 Structure

CAS #: 77591-33-4

Molecular Formula: C₂₁₂H₃₅₀N₅₆O₇₈S

Molecular Weight: 4963.5 g/mol

PubChem ID: 16132321

Research Findings

TB-500 has been studied in structural, vascular, epithelial, and systemic models, with research exploring its roles in collagen organization, extracellular matrix remodeling, angiogenesis, molecular migration, and pathway activity in preclinical settings.

Key Areas of Research:

  • Structural: Collagen, matrix, tendon/ligament

  • Vascular: Angiogenesis, nitric oxide, remodeling

  • Epithelial: Migration, signaling, matrix

  • Systemic: Signaling, viability, pathway dynamics

Together, these findings suggest broad experimental utility for TB-500 across multiple biological pathways. By engaging structural and vascular processes and supporting epithelial and systemic responses, TB-500 provides a versatile platform for investigating molecular remodeling, pathway dynamics, and resilience in laboratory settings.

Hsieh M.-J. et al., 2017

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10mg, 20mg, 2mg, 5mg

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Access to this website is restricted to individuals who are 21 years of age or older, reside in the United States, and are qualified research professionals, institutions, or acting in an independent research capacity. All products offered on this website are sold strictly for in-vitro research use only and are not intended for human or animal consumption, clinical use, diagnostic use, or therapeutic purposes of any kind. By proceeding, you acknowledge and confirm that you meet these qualifications and understand the research-only nature and intended use of these products.